The protective effects of enriched environment have been shown in traumatic, ischemic and toxic nervous system lesions. Monosodium glutamate (MSG) is a commonly used taste enhancer causing excitotoxic effects when given in newborn animals. We have previously demonstrated that MSG leads to a delay in neurobehavioral development, as shown by the delayed appearance of neurological reflexes and maturation of motor coordination. In the present study we aimed at investigating whether environmental enrichment is able to decrease the neurobehavioral delay caused by neonatal MSG treatment. I want to build my career in the field of management and planning to apply for MBA admission in Virata School of Business which is located in. Graduate Program Admission Test (GPAT) 10 April 2016, 7:30am. On admission: either a 2 drug. The patients were subjected for Schirmer's Test, 1% Rose Bengal Tearfilm break up time with Fluroscein and Conjunctival impression cytology. Significant decrease in thermal conductivity of multi-walled carbon nanotube induced by inter-wall van der Waals interactions. NASA Astrophysics Data System (ADS) Zhang, Xue; Zhou. UP GPAT (Graduate Programs Admission Test). Hope you all pass the GPAT. Newborn pups were treated with MSG subcutaneously on postnatal days 1, 5 and 9. For environmental enrichment, we placed rats in larger cages, supplemented with different toys that were altered daily. Normal control and enriched control rats received saline treatment only. Up Cba Graduate Program Admission Test GpatindiaGet wake-up call By ALICIA LEONARD. Asosiasi Aparel Manufaktur Indonesia ASEAN-Australia Media & Information Programme Akademi Akuntansi dan Manajemen Program Komputer Akademi. Asian Graduate School of. All Up Weight Avenue. Glossary of Acronyms and Abbreviations. Arrow System Improvement Program. Take either the Graduate Program Admission Test. Graduate Program Admission Test (GPAT) 10 April 2016. 4:59 AM by UP Virata School of Business Workshop Schedule 2016 Posted May 30, 2016, 6:40 PM by. UP GPAT (Graduate Programs Admission Test) X. Is it the same with other graduate program, the fee per unit of which is P600? Physical parameters such as weight, day of eye opening, incisor eruption and ear unfolding were recorded. Animals were observed for appearance of reflexes such as negative geotaxis, righting reflexes, fore- and hindlimb grasp, fore- and hindlimb placing, sensory reflexes and gait. In cases of negative geotaxis, surface righting and gait, the time to perform the reflex was also recorded daily. For examining motor coordination, we performed grid walking, footfault, rope suspension, rota- rod, inclined board and walk initiation tests. We found that enriched environment alone did not lead to marked alterations in the course of development. On the other hand, MSG treatment caused a slight delay in reflex development and a pronounced delay in weight gain and motor coordination maturation. This delay in most signs and tests could be reversed by enriched environment: MSG- treated pups kept under enriched conditions showed no weight retardation, no reflex delay in some signs and. The reduction of oxidative stress by nanocomposite Fullerol decreases mucositis severity and reverts leukopenia induced by Irinotecan. Pub. Med. Arifa, Raquel Duque Nascimento; Paula, Talles Prosperi de; Madeira, Mila Fernandes Moreira; Lima, Renata Lacerda; Garcia, Z. However, this therapy is associated with side effects, including leukopenia and mucositis. Reactive oxygen species (ROS) activate inflammatory pathways and contribute to Irinotecan- induced mucositis. Fullerol is a nanocomposite with anti- oxidant properties that may reduce tissue damage after inflammatory stimuli. In this paper, the effects of Fullerol and mechanisms of protection were investigated in a model of Irinotecan- induced mucositis. Mucositis was induced by an injection of Irinotecan per 4 days in C5. BL/6. Fullerol or a vehicle was injected every 1. On day 7, the intestines were removed to evaluate histological changes, leukocyte influx, and the production of cytokines and ROS. Irinotecan therapy resulted in weight loss, an increased clinical score and intestinal injury. Treatment with Fullerol attenuated weight loss, decreased clinical score and intestinal damage. Irinotecan also induced increased ROS production in enterocytes, oxidative stress, IL- 1. Fullerol treatment decreased production of ROS in the enterocytes, oxidative stress, IL- 1. Irinotecan therapy also induced leukopenia in an ROS- dependent manner because leukopenia reverted in WT mice treated with Fullerol or Apocynin or in Gp. Mice treated with Irinotecan presented less melanoma tumor growth compared to the control group. Fullerol does not interfere in the anti- tumor action of Irinotecan. Fullerol has a great pharmacology potential to decreases the severity of mucositis and of leukopenia during chemotherapy treatment. PMID: 2. 69. 87. 94. Doxazosin Treatment Attenuates Carbon Tetrachloride- Induced Liver Fibrosis in Hamsters through a Decrease in Transforming Growth Factor . Adrenergic receptor antagonists have been evaluated as antifibrotic drugs in rodent models of carbon tetrachloride (CCl. The aim of the present study was to evaluate the effects of carvedilol and doxazosin on fibrosis/cirrhosis in a hamster animal model. Methods Cirrhotic- induced hamsters were treated by daily administration of carvedilol and doxazosin for 6 weeks. Hepatic function and histological evaluation were conducted by measuring biochemical markers, including total bilirubin, aspartate aminotransferase, alanine aminotransferase and albumin, and liver tissue slices. Additionally, transforming growth factor . Results Biochemical markers revealed that hepatic function was restored after treatment with doxazosin and carvedilol. Histological evaluation showed a decrease in collagen type I deposits and TGF- . Conclusions Taken together, these results suggest that the decrease in collagen type I following treatment with doxazosin or carvedilol is achieved by decreasing the profibrotic activities of TGF- . Consequently, a diminution of fibrotic tissue in the CCl. PMID: 2. 65. 73. 29. Light- induced V. Riesen, Y.; Despeisse, M.; Sch. We observed a light- induced open- circuit voltage (V. After correction of the p- layer thickness for the increased surface area of rough substrates, we can exclude varying the effective p- layer thickness as the cause of the substrate roughness dependence. Instead, we explain the observations by an increase of the dangling- bond density in both the p- layer. We present a mechanism for the light- induced increase and decrease, justified by the investigation of light- induced changes of the p- layer and supported by Advanced Semiconductor Analysis simulation. We conclude that a shift of the electron quasi- Fermi level towards the conduction band is the reason for the observed V. To gain insight into the molecular events induced by low body temperature, liver proteins were evaluated at the standard laboratory rearing temperature (2. Using nano- flow liquid chromatography coupled with tandem mass spectrometry, we identified 5. A subsequent Gene Ontology analysis revealed that the tyrosine and phenylalanine catabolic processes were modulated by cold exposure, which resulted in decreases in hepatic tyrosine and phenylalanine, respectively. Similarly, levels of pyruvate kinase and enolase, which are involved in glycolysis and glycogen synthesis, were also decreased, whereas levels of glycogen phosphorylase, which participates in glycogenolysis, were increased. Therefore, we measured metabolites in the respective pathways and found that levels of hepatic glycogen and glucose were decreased. Although the liver was under oxidative stress because of iron accumulation caused by hepatic erythrocyte destruction, the hepatic NADPH/NADP ratio was not changed. Thus, glycogen is probably utilized mainly for NADPH supply rather than for energy or glucose production. PMID: 2. 41. 67. 71. Involvement of decreased glutamate receptor subunit Glu. R2 expression in lead- induced neuronal cell death. Pub. Med. Ishida, Keishi; Kotake, Yaichiro; Miyara, Masatsugu; Aoki, Kaori; Sanoh, Seigo; Kanda, Yasunari; Ohta, Shigeru. Lead is known to induce neurotoxicity, particularly in young children, and Glu. R2, an AMPA- type glutamate receptor subunit, plays an important role in neuronal cell survival. Therefore, we hypothesized that altered Glu. R2 expression plays a role in lead- induced neuronal cell death. To test this idea, we investigated the effect of exposure to 5 and 2. The number of trypan- blue stained cells was increased by exposure to 5 . Glu. R2 expression was reduced by exposure to 5- 1. Immunocytochemistry also confirmed that Glu. R2 expression was decreased in the presence of lead. Application of 5. BDNF) led to a recovery of lead- induced neuronal cell death, accompanied with increased Glu. R2 expression. Our results suggest that long- term exposure to lead induces neuronal cell death, in association with a decrease of Glu. R2 expression. PMID: 2. Anisomycin- induced GATA- 6 degradation accompanying a decrease of proliferation of colorectal cancer cell. Pub. Med. Ushijima, Hironori; Horyozaki, Akiko; Maeda, Masatomo. Transcription factor GATA- 6 plays a key role in normal cell differentiation of the mesoderm and endoderm. On the other hand, GATA- 6 is abnormally overexpressed in many clinical gastrointestinal cancer tissue samples, and accelerates cell proliferation or an anti- apoptotic response in cancerous tissues. We previously showed that activation of the JNK signaling cascade causes proteolysis of GATA- 6. In this study, we demonstrated that anisomycin, a JNK activator, stimulates nuclear export of GATA- 6 in a colorectal cancer cell line, DLD- 1. Concomitantly, anisomycin remarkably inhibits the proliferation of DLD- 1. However, it did not induce apoptosis under growth arrest conditions. Furthermore, the growth of DLD- 1. Although 5- FU showed only a slight inhibitory effect on 3. D spheroid cultures, the same concentration of 5- FU together with a low concentration of anisomycin exhibited strong growth inhibition. These results suggest that the induction of GATA- 6 dysfunction may be more effective for chemotherapy for colorectal cancer, although the mechanism underlying the synergistic effect of 5- FU and anisomycin remains unknown. PMID: 2. 74. 04. 12. Blueberry treatment decreased D- galactose- induced oxidative stress and brain damage in rats. Pub. Med. We investigated the effect of whole fresh blueberry (BB) (Vaccinium corymbosum L.) treatment on oxidative stress in age- related brain damage model. Rats received GAL (3. BB1) and 1. 0 % (BB2) BB containing chow for two months. Malondialdehyde (MDA),protein carbonyl (PC) and glutathione (GSH) levels, and Cu Zn- superoxide dismutase (SOD), glutathione peroxidase (GSH- Px) and glutathione transferase (GST) activities as well as acetylcholinesterase (ACh. E) activities were determined. Expressions of B cell lymphoma- 2 (Bcl- 2), Bax and caspase- 3 were also evaluated in the brain by immunohistochemistry. MDA and PC levels and ACh. E activity increased, but GSH levels, SOD and GSH- Px activities decreased together with histopathological structural damage in the brain of GAL- treated rats.
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